Consanguinity, Fertility and Reproductive Outcomes: An International Review

Consanguineous marriages have been common throughout human history, and remain so even today in many parts of the world. Many Arab countries display some highest rates consanguinity and, specifically, first cousin which may encompass 25 to 30 percent all marriages. The effects inbreeding on reproductive outcome extensively studied. It used be generally believed that contributed increased mortality morbidity with detrimental outcome; however, studies shown only a moderate slight impact. fertility consanguineous couples infant childhood their progeny also studied numerous concluded is not associated either significant positive or negative effect fertility. majority found produce more children. In cases mean number live births women has reported as being higher than non-consanguineous unions, although several lower couples. general, total Reports regarding association fetal wastage are conflicting, reporting prenatal losses were essentially same for non-consanguineous. Congenital malformations long established about background rate (4.5% vs 1%). Due principle existence ancestor. Consanguinity most commonly inborn errors metabolism, autosomal recessive. increases incidence multi-factorial disorders such diabetes, cardiovascular disorders, obesity certain types cancers, turn affect outcomes. Pregnancy outcomes, pregnancy preterm labor outcomes mostly due recessive inherited conditions metabolism. future, completion study whole Genome current advances pre-implantation diagnosis screening it possible mitigate adverse consanguinity.